Development of a novel rat model of lumbar facet joint osteoarthritis induced by persistent compressive injury
نویسندگان
چکیده
منابع مشابه
Development of a lumbar facet joint replacement
ii To Jameson and my parents iii We gain strength, and courage, and confidence by each experience in which we really stop to look fear in the face…we must do that which we think we cannot. Eleanor Roosevelt iv ACKNOWLEDGMENTS First, I want to thank my advisor Dr. Nicole Grosland. I would not be where I am without her guidance early in my college career. The insight and encouragement provided th...
متن کاملLumbar Facet Joint Compressive Injury Induces Lasting Changes in Local Structure, Nociceptive Scores, and Inflammatory Mediators in a Novel Rat Model
Objective. To develop a novel animal model of persisting lumbar facet joint pain. Methods. Sprague Dawley rats were anaesthetized and the right lumbar (L5/L6) facet joint was exposed and compressed to ~1 mm with modified clamps applied for three minutes; sham-operated and naïve animals were used as control groups. After five days, animals were tested for hind-paw sensitivity using von Frey fila...
متن کاملEstablishment of a rat model of lumbar facet joint osteoarthritis using intraarticular injection of urinary plasminogen activator
Lumbar facet joint (LFJ) osteoarthritis (OA) is an important etiology of low back pain. Several animal models of LFJ OA have been established using intraarticular injection of various chemicals. This study aimed to establish a rat model of LFJ OA using urinary plasminogen activator (uPA). Sprague-Dawley rats were treated with intraarticular injection in the L5-L6 facet joints with uPA (OA group...
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Background: Radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. Materials and Methods: 50 female Wistar rats were randomly divided into 5 groups, average 10 rats/cage: A. control group B. 3Gy×10f C. 6Gy×5f D. 12.5Gy×1f E.15.3Gy×1f....
متن کاملSeptic arthritis of a lumbar facet joint.
Patients occasionally present with sudden onset of back pain, deformity and fever but with radiographs which, though taken after an appropriate interval, seem to exclude sepsis in the disc or vertebral body. Since there are many synovial joints in the spine, it seemed possible that septic arthritis of a facet joint might explain the discrepancy. A search of the world literature back to 1966, ho...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2020
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2020.9117